A recent study conducted by researchers at the University of California Irvine has revealed that a natural compound found in green tea, when combined with the vitamin nicotinamide, may help protect against the buildup of waste associated with Alzheimer’s disease. This promising discovery highlights the potential of dietary supplements in addressing age-related cognitive decline.
The research focuses on epigallocatechin gallate (EGCG), a powerful antioxidant, and nicotinamide, a form of vitamin B3 that the body produces from niacin-rich foods such as cereals, fish, nuts, legumes, and eggs. The findings suggest that these compounds, readily available through a healthy diet and as safe dietary supplements, may play a significant role in maintaining brain health.
Boosting Brain Energy for Healthier Function
According to biomedical engineer Gregory Brewer, “By supplementing the brain’s energy systems with compounds that are already available as dietary supplements, we may have a new path toward treating age-related cognitive decline and Alzheimer’s disease.” The study demonstrated that in laboratory tests on mouse neurons, the combination of EGCG and nicotinamide increased levels of guanosine triphosphate (GTP), an essential energy molecule found in brain cells.
GTP is crucial for the removal of dead cells, and a deficiency has been linked to the development of Alzheimer’s disease. The research indicated that neurons with elevated GTP levels can effectively eliminate harmful amyloid beta protein clumps, which are associated with the progression of Alzheimer’s. Furthermore, the compounds showed potential in reversing age-related damage in brain cells.
The researchers noted that GTP levels tend to decline over time, particularly in the context of neurodegeneration. They hypothesize that the combination of EGCG and nicotinamide could restore GTP levels to those typically seen in younger cells. Brewer emphasized that “this study highlights GTP as a previously underappreciated energy source driving vital brain functions.”
Previous Research and Future Implications
Earlier studies have linked green tea consumption with a reduction in white matter lesions in the brain, subsequently lowering dementia risk, although direct causation was not established. Additionally, nicotinamide has shown protective effects on neurons against stroke and neurodegeneration. The current findings suggest that GTP may be a contributing factor behind these benefits, further underscoring the importance of EGCG and nicotinamide working synergistically.
While these results are encouraging, it is important to note that the research has only been tested on mouse cells in vitro. Brewer cautioned that significant time and further research will be necessary before these findings can lead to viable treatments for humans. He stated, “As people age, their brains show a decline in neuronal energy levels, which limits the ability to remove unwanted proteins and damaged components. We found that restoring energy levels helps neurons regain this critical cleanup function.”
The study has been published in the journal GeroScience, contributing valuable insights into the relationship between diet, brain health, and the potential prevention of Alzheimer’s disease. As research continues to evolve, the prospect of utilizing everyday dietary elements to combat cognitive decline remains a hopeful avenue for future advancements in geriatric health.
